What Is SOMATULINE® DEPOT (lanreotide) Injection 120 mg?

A Different Treatment for Gastrointestinal and Pancreatic Neuroendocrine Tumors (GEP-NETs)

SOMATULINE DEPOT is the first prescription medicine approved by the United States Food and Drug Administration (FDA) to treat adult patients GEP-NETs by slowing down disease progression in either gastrointestinal or pancreatic NETs that have spread or cannot be removed by surgery.

A Lower Chance of Disease Growing or Spreading

Compared with placebo, the chance of neuroendocrine cancer spreading or growing was lowered by 53% with SOMATULINE DEPOT.

Somatuline Depot vs. placebo reduced risk of progression or death by 53%

The majority of patients on SOMATULINE DEPOT did not yet experience disease progression during the 22-month study, while half of patients on placebo had disease progression by 16.6 months.

SELECT IMPORTANT SAFETY INFORMATION

Who should not take SOMATULINE DEPOT?

Do not take SOMATULINE DEPOT if you are allergic to lanreotide.

To learn more, please see additional Important Safety Information throughout this website or go to this icon located at the top of the page.

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SOMATULINE® DEPOT(lanreotide) Injection 120 mg: How Does It Work?

A Synthetic Version of a Natural Hormone

SOMATULINE DEPOT is a synthetic version of a hormone called somatostatin, which is found naturally in the human body.

Natural somatostatin helps to control the release of many different types of hormones. Somatostatin can also help to control the growth of tumors in the body.

Although SOMATULINE DEPOT is designed to work similarly to natural somatostatin, it is not known exactly how it works to delay the growth of gastrointestinal or pancreatic neuroendocrine tumors (NETs) in this patient population.

SOMATULINE DEPOT Is the First Prescription Medicine...

Approved by the United States Food and Drug Administration (FDA) to treat gastroenteropancreatic NETs by slowing down disease progression in either gastrointestinal or pancreatic NETs that have spread or cannot be removed by surgery.

SELECT IMPORTANT SAFETY INFORMATION

What are the possible side effects of SOMATULINE DEPOT?

SOMATULINE DEPOT may cause serious side effects, including:

  • Gallstones. Tell your healthcare professional if you get any of these symptoms:
    • sudden pain in your upper right stomach area (abdomen)
    • sudden pain in your right shoulder or between your shoulder blades
    • yellowing of your skin and whites of your eyes
    • fever with chills
    • nausea
  • Changes in your blood sugar (high blood sugar or low blood sugar). If you have diabetes, test your blood sugar as your healthcare professional tells you to. Your healthcare professional may change your dose of diabetes medicine.
  • Slow heart rate
  • High blood pressure

The most common side effects of SOMATULINE DEPOT in people with GEP-NETs include stomach area (abdominal) pain, muscle and joint aches, vomiting, headache, and pain, itching, or a lump at the injection site.

SOMATULINE DEPOT may cause dizziness. If this happens, do not drive a car or operate machinery.

To learn more, please see additional Important Safety Information throughout this website or go to this icon located at the top of the page.

Personalized Support: IPSEN CARES can help you navigate your insurance coverage process for SOMATULINE DEPOT.

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SOMATULINE® DEPOT(lanreotide) Injection 120 mg: How Was It Studied?

Studied in Patients With Different Types of GEP-NETs

SOMATULINE DEPOT was studied for nearly 2 years in people with various types of gastrointestinal and pancreatic neuroendocrine tumors (GEP-NETs) that had spread or could not be removed by surgery. In some people, the cancer started in their pancreas. In others, it started in a different place, such as their colon or intestines.

People who participated in the study were divided into 2 patient groups and given either SOMATULINE DEPOT or placebo.

The 2 patient groups in the study were similar:

  • Both groups included patients who had a variety of tumor types and treatment histories
  • The average age of the patients was 63 years
  • Before they entered this study, some people had received other treatments for GEP-NETs, including surgery, chemotherapy, or other drug therapy, but not within 6 months of the start of the study
  • Most people in the study (84%) had not received any form of medical therapy for their GEP-NETs before the study

At study entry there was one difference between the 2 groups:

  • More patients in the SOMATULINE DEPOT group compared with placebo (39% vs 27%) had cancer in a large portion (more than 25%) of their liver

Slow the Growth or Spread of GEP-NETs

The majority of patients on SOMATULINE DEPOT did not yet experience disease progression during the 22-month study, while half of patients on placebo had disease progression by 16.6 months.

HOW CAN SOMATULINE DEPOT HELP?Find Out More

What is SOMATULINE® DEPOT (lanreotide) Injection 120 mg?

SOMATULINE DEPOT is a prescription medicine used for the treatment of adult patients with a type of cancer, known as neuroendocrine tumors, from the gastrointestinal tract or the pancreas (GEP-NETs) that has spread or cannot be removed by surgery.

It is not known if SOMATULINE DEPOT is safe and effective in children.

IMPORTANT SAFETY INFORMATION

Who should not take SOMATULINE DEPOT?

Do not take SOMATULINE DEPOT if you are allergic to lanreotide.

What are the possible side effects of SOMATULINE DEPOT?

SOMATULINE DEPOT may cause serious side effects, including:

  • Gallstones. Tell your healthcare professional if you get any of these symptoms:
    • sudden pain in your upper right stomach area (abdomen)
    • sudden pain in your right shoulder or between your shoulder blades
    • yellowing of your skin and whites of your eyes
    • fever with chills
    • nausea
  • Changes in your blood sugar (high blood sugar or low blood sugar). If you have diabetes, test your blood sugar as your healthcare professional tells you to. Your healthcare professional may change your dose of diabetes medicine.
  • Slow heart rate
  • High blood pressure

The most common side effects of SOMATULINE DEPOT in people with GEP-NETs include stomach area (abdominal) pain, muscle and joint aches, vomiting, headache, and pain, itching, or a lump at the injection site.

SOMATULINE DEPOT may cause dizziness. If this happens, do not drive a car or operate machinery.

What should I tell my healthcare professional before receiving SOMATULINE DEPOT?

  • Tell your healthcare professional if you have diabetes or gallbladder, thyroid, heart, kidney, or liver problems.
  • Tell your healthcare professional if you are pregnant or plan to become pregnant as SOMATULINE DEPOT may harm your unborn baby. Tell your healthcare professional if you are breastfeeding or plan to breastfeed. It is not known if SOMATULINE DEPOT passes into your breast milk. You and your healthcare professional should decide if you will take SOMATULINE DEPOT or breastfeed. You should not do both.
  • Tell your healthcare professional about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. SOMATULINE DEPOT and other medicines may affect each other, causing side effects. SOMATULINE DEPOT may affect the way other medicines work, and other medicines may affect how SOMATULINE DEPOT works.
  • Especially tell your healthcare professional if you take insulin or other diabetes medicines, a cyclosporine (Gengraf, Neoral, or Sandimmune), a medicine called bromocriptine (Parlodel, Cycloset), or medicines that lower your heart rate, such as beta blockers.

Tell your healthcare professional if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of SOMATULINE DEPOT. For more information ask your healthcare professional.

You may report side effects to FDA at 1‑800‑FDA‑1088 or Ipsen Biopharmaceuticals, Inc. at 1‑888‑980‑2889.

Please click here for Patient Information and full Prescribing Information.

Enroll Today: IPSEN CARES representatives are available from 8 am to 8 pm ET (5 am to 5 pm PT) Monday through Friday: 1‑866‑435‑5677.

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Important Safety Information

What is SOMATULINE® DEPOT (lanreotide) Injection 120 mg?

SOMATULINE DEPOT is a prescription medicine used for the treatment of adult patients with a type of cancer, known as neuroendocrine tumors, from the gastrointestinal tract or the pancreas (GEP-NETs) that has spread or cannot be removed by surgery.

It is not known if SOMATULINE DEPOT is safe and effective in children.

IMPORTANT SAFETY INFORMATION

Who should not take SOMATULINE DEPOT?

Do not take SOMATULINE DEPOT if you are allergic to lanreotide.

What are the possible side effects of SOMATULINE DEPOT?

SOMATULINE DEPOT may cause serious side effects, including:

  • Gallstones. Tell your healthcare professional if you get any of these symptoms:
    • sudden pain in your upper right stomach area (abdomen)
    • sudden pain in your right shoulder or between your shoulder blades
    • yellowing of your skin and whites of your eyes
    • fever with chills
    • nausea
  • Changes in your blood sugar (high blood sugar or low blood sugar). If you have diabetes, test your blood sugar as your healthcare professional tells you to. Your healthcare professional may change your dose of diabetes medicine.
  • Slow heart rate
  • High blood pressure

The most common side effects of SOMATULINE DEPOT in people with GEP-NETs include stomach area (abdominal) pain, muscle and joint aches, vomiting, headache, and pain, itching, or a lump at the injection site.

SOMATULINE DEPOT may cause dizziness. If this happens, do not drive a car or operate machinery.

What should I tell my healthcare professional before receiving SOMATULINE DEPOT?

  • Tell your healthcare professional if you have diabetes or gallbladder, thyroid, heart, kidney, or liver problems.
  • Tell your healthcare professional if you are pregnant or plan to become pregnant as SOMATULINE DEPOT may harm your unborn baby. Tell your healthcare professional if you are breastfeeding or plan to breastfeed. It is not known if SOMATULINE DEPOT passes into your breast milk. You and your healthcare professional should decide if you will take SOMATULINE DEPOT or breastfeed. You should not do both.
  • Tell your healthcare professional about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. SOMATULINE DEPOT and other medicines may affect each other, causing side effects. SOMATULINE DEPOT may affect the way other medicines work, and other medicines may affect how SOMATULINE DEPOT works.
  • Especially tell your healthcare professional if you take insulin or other diabetes medicines, a cyclosporine (Gengraf, Neoral, or Sandimmune), a medicine called bromocriptine (Parlodel, Cycloset), or medicines that lower your heart rate, such as beta blockers.

Tell your healthcare professional if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of SOMATULINE DEPOT. For more information ask your healthcare professional.

You may report side effects to FDA at 1‑800‑FDA‑1088 or Ipsen Biopharmaceuticals, Inc. at 1‑888‑980‑2889.

Please click here for Patient Information and full Prescribing Information.