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by talking to your doctor about your 
treatment options.

Somatuline® Depot is the 1st and only FDA-approved treatment for adults to slow the growth of gastrointestinal and pancreatic neuroendocrine tumors (GEP‑NETs) that have spread or cannot be removed by surgery...and treat carcinoid syndrome to reduce the need for the use of short-acting somatostatin medicine.*

*It is not known if Somatuline Depot is safe and effective in children.

Explore 3 reasons why Somatuline Depot may be an option for you


1 Slow the Growth of GEP-NETs

In adults whose disease has spread or cannot be removed by surgery

  • Somatuline Depot was studied for nearly 2 years in patients with various types of GEP-NETs that had spread or could not be removed by surgery. In some patients, the cancer started in their pancreas. In others, it started in a different place, such as their intestinal tract, which includes the colon
  • Patients in the study were divided into 2 groups, which received either Somatuline Depot 120 mg or placebo by injection every 4 weeks
  • Somatuline Depot versus placebo reduced the risk of disease progression or death by 53%
  • At 22 months, more than half of the patients taking Somatuline Depot did not yet have their cancer progress. For those taking placebo, it took 16.6 months until half the patients had their cancer progress

What are GEP-NETs?

Gastrointestinal and pancreatic neuroendocrine tumors, or GEP-NETs, are a type of cancer that can occur in either the pancreas or gastrointestinal tract.

Talk to your doctor about your condition and whether Somatuline Depot is right for you.

Please see below for more information about the possible side effects of Somatuline Depot.


2 Carcinoid Syndrome

Somatuline Depot is FDA-approved to treat adults with carcinoid syndrome to reduce the need for the use of short-acting somatostatin medicine.

What is carcinoid syndrome?

Carcinoid syndrome occurs when a rare cancerous tumor called a neuroendocrine tumor secretes certain chemicals into your bloodstream, causing signs and symptoms.

What is somatostatin?

Somatostatin is a natural hormone found in the body that slows cell growth, along with the release of other hormones in the body—including hormones found in the gastrointestinal tract and pancreas.

Talk to your doctor about your condition and whether Somatuline Depot is right for you. A conversation on side effects is an important part of talking to your doctor about treatment options.


3 Once-Monthly, Sustained-Release Injection

  • You will receive a Somatuline Depot deep subcutaneous injection every 4 weeks, given by your healthcare provider
  • Your healthcare provider will tell you how long you need to receive Somatuline Depot
  • Somatuline Depot is injected deep under the skin of the upper outer area of your buttock
  • Your injection site should change (alternate) between your right and left buttock from one injection of Somatuline Depot to the next
  • If you're already being treated with Somatuline Depot for GEP-NETs, your doctor will not give you an additional dose to treat carcinoid syndrome

What Are the Possible Side Effects?

It's important to talk to your doctor about the risks associated with Somatuline Depot

Do not take Somatuline Depot if you are allergic to lanreotide.

Somatuline Depot may cause serious side effects, including: gallstones, changes to your blood sugar (high or low blood sugar), slow heart rate, and high blood pressure.

Tell your healthcare provider (HCP) if you have any of the following symptoms:

  • Symptoms of gallstones may include sudden pain in your upper right stomach area (abdomen), sudden pain in your right shoulder or between your shoulder blades, yellowing of your skin and whites of your eyes, fever with chills, and nausea
  • Symptoms of high blood sugar may include increased thirst, increased appetite, nausea, weakness or tiredness, urinating more than normal, and fruity smelling breath
  • Symptoms of low blood sugar may include dizziness or lightheadedness, sweating, confusion, headache, blurred vision, slurred speech, shakiness, fast heartbeat, irritability or mood changes, and hunger
  • Symptoms of slow heart rate may include dizziness or lightheadedness, fainting or near-fainting, chest pain, shortness of breath, confusion or memory problems, and weakness or extreme tiredness

The most common side effects of Somatuline Depot in people with:

  • GEP-NETs: stomach area (abdominal) pain; muscle and joint aches; vomiting; headache; pain, itching or a lump at the injection site
  • Carcinoid syndrome: headache, dizziness, muscle spasm; side effects were generally similar to those commonly seen with GEP-NETs

Before taking Somatuline Depot, tell your HCP about all your medical conditions including if you: have diabetes; have gallbladder, heart, thyroid, kidney or liver problems; are pregnant or plan to become pregnant; or are breastfeeding or plan to breastfeed. It is not known if Somatuline Depot will harm your unborn baby or pass into breast milk. You should not breastfeed if you receive Somatuline Depot and for 6 months after your last dose. Somatuline Depot may affect your ability to become pregnant.

This is not a full list of all possible side effects or information you should tell your healthcare provider. Please see below for additional Important Safety Information.

Savings & Support

Copay assistance reimbursement support at your fingertips

Eligible patients may save up to $20,000 per year with no monthly limit* and pay as little as $5 per prescription

Ipsen is proud to present IPSEN CARES®, our Coverage, Access, Reimbursement & Education Support program—providing a range of Somatuline® Depot patient support. The goal of IPSEN CARES is to help simplify interactions between you, your insurance company, and your doctor’s office. With a wide range of services, IPSEN CARES helps support your treatment process every step of the way.

To enroll, visit IPSEN CARES or call (866) 435-5677 between the hours of 8 am to 8 pm ET Monday through Friday to speak with an IPSEN CARES representative.

*Please see Patient Eligibility and Terms & Conditions. Some patients may pay more than $5.


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