Explore 3 reasons with your doctor why Somatuline Depot may be an option for you
Slow the growth of GEP-NETs
In adults whose disease has spread or cannot be removed by surgery
In clinical studies, Somatuline Depot reduced the risk of disease progression or death by 53% versus placebo.
At 22 months, more than half of the patients taking Somatuline Depot did not yet have their cancer progress. For those taking placebo, it took 16.6 months until half the patients had their cancer progress.
How Somatuline Depot was studied
- Somatuline Depot was studied for nearly 2 years in 204 adult patients with various types of GEP-NETs that had spread or could not be removed by surgery. In some patients, the cancer started in their pancreas. In others, it started in a different place, such as their intestinal tract, which includes the colon
- Patients in the study were divided into 2 groups, which received either Somatuline Depot 120 mg or placebo by deep subcutaneous injection every 4 weeks
- The primary goal of this study was to determine if Somatuline Depot improved progression-free survival, which is the amount of time it took for the disease to progress
Learn about the possible side effects of Somatuline Depot
Somatuline Depot is FDA-approved to treat adults with carcinoid syndrome to reduce the need for the use of short-acting somatostatin medicine.
Once-monthly, sustained-release injection
Somatuline Depot is approved as a deep subcutaneous injection given every 4 weeks by a healthcare provider. Your healthcare provider may change your dose of Somatuline Depot or the length of time between your injections.
Safe’n’Sound® syringe technology. Safe’n’Sound is a registered trademark of NEMERA LA VERPILLIERE SAS.
Not actual size.
Somatuline Depot is given by your healthcare provider as a low-volume, single-use syringe
- Somatuline Depot is injected deep under the skin of the upper outer area of your buttock
- Your injection site should change (alternate) between your right and left buttock from one injection of Somatuline Depot to the next
- If you’re already being treated with Somatuline Depot for GEP-NETs, your doctor will not give you an additional dose to treat carcinoid syndrome
- Please click here for Full Prescribing Information Including Instructions for Use
How Somatuline Depot works
- Somatuline Depot contains lanreotide, a synthetic, or man-made, version of a hormone called somatostatin, which is found naturally in the human body
- It is believed that each injection forms a reservoir of the medicine between the skin surface and the muscle beneath—in an area called the deep subcutaneous tissue
- Over time, tiny parts of the reservoir are slowly released into your bloodstream, to deliver the medicine to the rest of your body. This innovative formulation is what allows Somatuline Depot to be slowly released over the course of a month
How it works
Facts about Somatuline Depot
IMPORTANT SAFETY INFORMATION & INDICATIONS
- Do not take SOMATULINE DEPOT if you are allergic to lanreotide.
- SOMATULINE DEPOT may cause serious side effects, including:
- Changes to your blood sugar (high or low blood sugar),
- Slow heart rate, and
- High blood pressure.
- Tell your healthcare provider (HCP) if you have any of the following symptoms:
- Symptoms of gallstones may include sudden pain in your upper right stomach area (abdomen), sudden pain in your right shoulder or between your shoulder blades, yellowing of your skin and whites of your eyes, fever with chills, and nausea.
- Symptoms of high blood sugar may include increased thirst, increased appetite, nausea, weakness or tiredness, urinating more than normal, and fruity smelling breath.
- Symptoms of low blood sugar may include dizziness or lightheadedness, sweating, confusion, headache, blurred vision, slurred speech, shakiness, fast heartbeat, irritability or mood changes, and hunger.
- Symptoms of slow heart rate may include dizziness or lightheadedness, fainting or near-fainting, chest pain, shortness of breath, confusion or memory problems, and weakness or extreme tiredness.
- The most common side effects of SOMATULINE DEPOT in people with:
- GEP-NETs: stomach area (abdominal) pain; muscle and joint aches; vomiting; headache; pain, itching or a lump at the injection site
- Carcinoid syndrome: headache, dizziness, muscle spasm; side effects were generally similar to those commonly seen with GEP‑NETs
- SOMATULINE DEPOT may cause dizziness. If this happens, do not drive a car or operate machinery.
- Tell your HCP right away if you have signs of an allergic reaction after receiving SOMATULINE DEPOT, including swelling of your face, lips or tongue; breathing problems; fainting, dizziness or feeling lightheaded (low blood pressure); itching; skin flushing or redness; rash; or hives.
- Before taking SOMATULINE DEPOT, tell your HCP about all your medical conditions including if you: have diabetes; have gallbladder, heart, thyroid, kidney or liver problems; are pregnant or plan to become pregnant; or are breastfeeding or plan to breastfeed. It is not known if SOMATULINE DEPOT will harm your unborn baby or pass into breast milk. You should not breastfeed if you receive SOMATULINE DEPOT and for 6 months after your last dose. SOMATULINE DEPOT may affect your ability to become pregnant.
- Tell your HCP about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. SOMATULINE DEPOT and other medicines may affect each other, causing side effects. SOMATULINE DEPOT may affect the way other medicines work, and other medicines may affect how SOMATULINE DEPOT works. Your dose of SOMATULINE DEPOT or your other medications may need to be changed. If you have diabetes, your HCP may change your dose of diabetes medication when you first start receiving SOMATULINE DEPOT or if your dose of SOMATULINE DEPOT is changed.
- Especially tell your HCP if you take:
- Insulin or other diabetes medicines,
- A cyclosporine (Gengraf, Neoral, or Sandimmune), or
- Medicines that lower your heart rate, such as beta blockers.
Know the medicines you take. Keep a list of them to show your HCP when you get a new medicine.
Tell your HCP if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of SOMATULINE DEPOT. For more information, ask your HCP.
To report SUSPECTED ADVERSE REACTIONS, contact Ipsen Biopharmaceuticals, Inc. at 1-855-463-5127 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
What is SOMATULINE® DEPOT (lanreotide) Injection?
SOMATULINE DEPOT is a prescription medicine used in adults for:
- the treatment of a type of cancer known as neuroendocrine tumors, from the gastrointestinal tract or the pancreas (GEP-NETs) that has spread or cannot be removed by surgery; and
- the treatment of carcinoid syndrome to reduce the need for the use of short-acting somatostatin medicine.
It is not known if SOMATULINE DEPOT is safe and effective in children.