TREATMENT

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ON TREATMENT

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Ask your doctor which option is best for you.

How is Somatuline® Depot (lanreotide) administered?

Somatuline Depot is an injection that should be given by a healthcare professional (or HCP) every 4 weeks.

Learn more about IPSEN CARES

As few as 7 doses a year for controlled patients^b,c

If your hormones and symptoms are controlled,^b,c your doctor may offer to:

Continue giving you the same dose, or
Increase the dose to 120 mg and give you injections less often—every 6 or 8 weeks, instead of every 4 weeks

^bIn patients whose acromegaly is controlled after 3 months of treatment. Controlled is defined as GH level from >1.0 ng/mL to ≤2.5 ng/mL, normalized IGF-1 level, and satisfactory management of clinical symptoms as determined by the healthcare provider. This dosing interval is based on controlled patients using 8-week dosing intervals after year 1.

^cPatients who are controlled with Somatuline Depot 60 mg or 90 mg administered every 4 weeks can be considered for treatment with 120 mg administered every 6 or 8 weeks. GH and IGF-1 levels should be obtained 6 weeks after this change in dosing regimen to evaluate persistence of patient response. Continued monitoring of patients’ responses with dose adjustments for biochemical and clinical symptom control, as necessary, is recommended.

Patients receiving
Somatuline Depot administered
once every 4 weeks

Patients receiving
Somatuline Depot 120 mg
administered once every 6 weeks

Patients receiving
Somatuline Depot 120 mg
administered once every 8 weeks

A once-monthly injection

Somatuline Depot is an injection administered by your healthcare provider with a syringe that was designed to streamline the injection process during your visit.

What can I expect during my visit?

Somatuline Depot is available as sterile, ready-to-use, single-dose prefilled syringes and is intended to be administered by a healthcare provider.

Somatuline Depot is given by deep subcutaneous injection – injected in the soft fatty layer of tissue.

The injection is given to you by a healthcare provider in the upper buttock, and it takes 20 seconds to complete
The injection site should alternate at each visit between the right and left buttock
Remember to remind your doctor that your skin must be spread (and not pinched) when you receive the injection
If you are already being treated with Somatuline Depot, no additional dose in the same month should be administered - inform your healthcare provider

For more information on what to expect during your visit, refer to the Patient Information and talk to your healthcare provider.

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How does it work in the body?

Somatuline Depot contains lanreotide, a synthetic, or man-made, version of a hormone called somatostatin, which is found naturally in the human body.

It is believed that each injection forms a reservoir of the medicine between the skin surface and the muscle beneath—in an area called the deep subcutaneous tissue.

Somatuline Depot is slowly released into the bloodstream, which is why you’re able to receive it at 1-month intervals.

IMPORTANT SAFETY INFORMATION & INDICATION

Do not take SOMATULINE DEPOT if you are allergic to lanreotide.

SOMATULINE DEPOT may cause serious side effects, including:

Gallstones

Fatty stool

Changes to your blood sugar (high or low blood sugar),

Slow heart rate,

High blood pressure, and

Changes in thyroid function in acromegaly patients.

Tell your healthcare provider (HCP) if you have any of the following symptoms:

Symptoms of gallstones may include sudden pain in your upper right stomach area (abdomen), sudden pain in your right shoulder or between your shoulder blades, yellowing of your skin and whites of your eyes, fever with chills, and nausea.

Fatty stool. SOMATULINE DEPOT may cause your body to have issues absorbing dietary fats. Tell your healthcare provider if you have any new or worsening symptoms including fatty stools, changes in the color of your stools, loose stools, stomach (abdominal) bloating or weight loss.

Symptoms of high blood sugar may include increased thirst, increased appetite, nausea, weakness or tiredness, urinating more than normal, and fruity smelling breath.

Symptoms of low blood sugar may include dizziness or lightheadedness, sweating, confusion, headache, blurred vision, slurred speech, shakiness, fast heartbeat, irritability or mood changes, and hunger.

Symptoms of slow heart rate may include dizziness or lightheadedness, fainting or nearfainting, chest pain, shortness of breath, confusion or memory problems, and weakness or extreme tiredness.

SOMATULINE DEPOT can cause the thyroid gland to not make enough thyroid hormone in people with acromegaly. Symptoms of low thyroid levels may include fatigue,
weight gain, puffy face, being cold all the time, constipation, dry skin, thinning or dry hair, decreased sweating, and depression.

The most common side effects of SOMATULINE DEPOT in people with acromegaly include diarrhea; stomach (abdominal) pain; nausea; and pain, itching, or a lump at the injection site.

SOMATULINE DEPOT may cause dizziness. If this happens, do not drive a car or operate machinery.

Tell your HCP right away if you have signs of an allergic reaction after receiving SOMATULINE DEPOT, including swelling of your face, lips or tongue; breathing problems; fainting, dizziness or feeling lightheaded (low blood pressure); itching; skin flushing or redness; rash; or hives.

Before taking SOMATULINE DEPOT, tell your HCP about all your medical conditions including if you: have diabetes; have gallbladder, heart, thyroid, kidney or liver problems; are pregnant or plan to become pregnant; or are breastfeeding or plan to breastfeed. It is not known if SOMATULINE DEPOT will harm your unborn baby or pass into breast milk. You should not breastfeed if you receive SOMATULINE DEPOT and for 6 months after your last dose. SOMATULINE DEPOT may affect your ability to become pregnant.

Tell your HCP about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. SOMATULINE DEPOT and other medicines may affect each other, causing side effects. SOMATULINE DEPOT may affect the way other medicines work, and other medicines may affect how SOMATULINE DEPOT works. Your dose of SOMATULINE DEPOT or your other medications may need to be changed. If you have diabetes, your HCP may change your dose of diabetes medication when you first start receiving SOMATULINE DEPOT or if your dose of SOMATULINE DEPOT is changed.

Especially tell your HCP if you take:

Insulin or other diabetes medicines,

A cyclosporine (Gengraf, Neoral, or Sandimmune), or

Medicines that lower your heart rate, such as beta blockers.

Know the medicines you take. Keep a list of them to show your HCP when you get a new medicine.

Tell your HCP if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of SOMATULINE DEPOT. For more information, ask your HCP.

To report SUSPECTED ADVERSE REACTIONS, contact Ipsen Biopharmaceuticals, Inc. at
1-855-463-5127 or FDA at 1-800-FDA-1088 or .

What is SOMATULINE® DEPOT (lanreotide) Injection?

SOMATULINE DEPOT is a prescription medicine used in adults for the long-term treatment of people with acromegaly when surgery or radiotherapy have not worked well enough or a patient is unable to have surgery or radiotherapy.

It is not known if SOMATULINE DEPOT is safe and effective in children.

STARTING & STAYINGON TREATMENT