About the Diagnosis

Get facts about gastrointestinal and pancreatic neuroendocrine tumors (GEP-NETs) and carcinoid syndrome and tools to help with discussions you have with your healthcare providers.

What are GEP-NETs?

GEP-NETs are a rare form of cancer, mostly found in the gastrointestinal (GI) tract or gut. GEP-NETs start in certain cells of the body’s neuroendocrine system which is made up of both nerve cells and hormone-producing cells. These cells help control many functions in the body, like how quickly food moves through and how food is digested by the GI tract.

What are GEP-NETs?

Signs and symptoms of GEP-NETs can include:

  • Cramps or abdominal pain
  • Weight loss
  • Fatigue
  • Bloating
  • Diarrhea
  • Nausea
  • Vomiting
  • Constipation
  • Flushing

In some cases, patients with GEP-NETs experience a group of symptoms known as carcinoid syndrome.

How are GEP-NETs discovered?

Many people with GEP-NETs often don’t have symptoms. And if their tumor is discovered, it’s often by chance. For others, symptoms can begin to arise due to the tumor’s growth.

Most GEP-NETs grow slowly, and if they do cause symptoms, those symptoms can be hard to pinpoint because they may seem like other conditions. Because of this, doctors are likely to explore other, more common diagnoses first. This can slow down a correct diagnosis—in some cases for several years.

An option for you?

Somatuline® Depot may be an option for people with certain GEP-NETs to discuss with their doctor

Learn Why

What is carcinoid syndrome?

A group of symptoms associated with carcinoid tumors

Some NETs are considered carcinoid tumors. Certain carcinoid tumors release hormones into your bloodstream and cause carcinoid syndrome.

What symptoms are included with carcinoid syndrome?

Two of the most common symptoms are diarrhea and flushing.

Learn Why

Somatuline Depot may be an option for people with carcinoid syndrome to discuss with their doctor

Many people with carcinoid tumors find that things like stress, heavy exercise, and drinking alcohol can trigger symptoms of carcinoid syndrome.

Not all carcinoid tumors cause carcinoid syndrome. For example, rectal carcinoid tumors usually don’t make the hormone-like substances that cause symptoms.

Most cases of carcinoid syndrome only occur once the cancer has spread to other parts of the body.

Carcinoid syndrome



Active dialogue

It’s important to work closely with your medical team at every step of your GEP-NETs and/or carcinoid syndrome diagnosis and treatment.

Explore Resources and Support   

to help you work with your medical team

Active dialogue

Reminders and discussion points

  • Check in with your medical team about any side effects and to monitor your overall health
  • Attend regular physical examinations and/or medical tests
  • Side effects can sometimes linger beyond the treatment period, and “late effects” may develop months or years afterward. It is important to talk to your doctor about the risk of developing these side effects

Take Charge Now

by learning about a treatment option for people with certain GEP-NETs and/or carcinoid syndrome to discuss with their doctor

Learn more


  • Do not take SOMATULINE DEPOT if you are allergic to lanreotide.
  • SOMATULINE DEPOT may cause serious side effects, including:
    • Gallstones 
    • Changes to your blood sugar (high or low blood sugar), 
    • Slow heart rateand 
    • High blood pressure.
  • Tell your healthcare provider (HCP) if you have any of the following symptoms: 
    • Symptoms of gallstones may include sudden pain in your upper right stomach area (abdomen), sudden pain in your right shoulder or between your shoulder blades, yellowing of your skin and whites of your eyes, fever with chills, and nausea.
    • Symptoms of high blood sugar may include increased thirst, increased appetite, nausea, weakness or tiredness, urinating more than normal, and fruity smelling breath.
    • Symptoms of low blood sugar may include dizziness or lightheadedness, sweating, confusion, headache, blurred vision, slurred speech, shakiness, fast heartbeat, irritability or mood changes, and hunger.
    • Symptoms of slow heart rate may include dizziness or lightheadedness, fainting or near-fainting, chest pain, shortness of breath, confusion or memory problems, and weakness or extreme tiredness.
  • The most common side effects of SOMATULINE DEPOT in people with: 
    • GEP-NETs: stomach area (abdominal) pain; muscle and joint aches; vomiting; headache; pain, itching or a lump at the injection site
    • Carcinoid syndrome: headache, dizziness, muscle spasm; side effects were generally similar to those commonly seen with GEP‑NETs
  • SOMATULINE DEPOT may cause dizziness. If this happens, do not drive a car or operate machinery.
  • Tell your HCP right away if you have signs of an allergic reaction after receiving SOMATULINE DEPOT, including swelling of your face, lips or tongue; breathing problems; fainting, dizziness or feeling lightheaded (low blood pressure); itching; skin flushing or redness; rash; or hives.
  • Before taking SOMATULINE DEPOT, tell your HCP about all your medical conditions including if you: have diabetes; have gallbladder, heart, thyroid, kidney or liver problems; are pregnant or plan to become pregnant; or are breastfeeding or plan to breastfeed. It is not known if SOMATULINE DEPOT will harm your unborn baby or pass into breast milk. You should not breastfeed if you receive SOMATULINE DEPOT and for 6 months after your last dose. SOMATULINE DEPOT may affect your ability to become pregnant.
  • Tell your HCP about all the medicines you take,  including prescription and over-the-counter medicines, vitamins, and herbal supplements. SOMATULINE DEPOT and other medicines may affect each other, causing side effects. SOMATULINE DEPOT may affect the way other medicines work, and other medicines may affect how SOMATULINE DEPOT works. Your dose of SOMATULINE DEPOT or your other medications may need to be changed. If you have diabetes, your HCP may change your dose of diabetes medication when you first start receiving SOMATULINE DEPOT or if your dose of SOMATULINE DEPOT is changed.
  • Especially tell your HCP if you take:
    • Insulin or other diabetes medicines,
    • A cyclosporine (Gengraf, Neoral, or Sandimmune), or
    • Medicines that lower your heart rate, such as beta blockers.

Know the medicines you take. Keep a list of them to show your HCP when you get a new medicine.

Tell your HCP if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of SOMATULINE DEPOT. For more information, ask your HCP.

To report SUSPECTED ADVERSE REACTIONS, contact Ipsen Biopharmaceuticals, Inc. at 1-855-463-5127 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

What is SOMATULINE® DEPOT (lanreotide) Injection? 

SOMATULINE DEPOT is a prescription medicine used in adults for:

  • the treatment of a type of cancer known as neuroendocrine tumors, from the gastrointestinal tract or the pancreas (GEP-NETs) that has spread or cannot be removed by surgery; and
  • the treatment of carcinoid syndrome to reduce the need for the use of short-acting somatostatin medicine.

It is not known if SOMATULINE DEPOT is safe and effective in children.

Please see full Prescribing Information, including Patient Information.

©2019 Ipsen Biopharmaceuticals, Inc. All rights reserved. March 2019 SMD-US-002659