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  • How is it Given?


Somatuline Depot 120 mg is a once-monthly injection administered by your healthcare provider with a syringe that was designed to streamline the injection process during your visit.


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What does this mean for you?

  • Prefilled—requires less preparation time by your healthcare provider
  • Sturdy plunger—designed to increase stability
  • Deep subcutaneous injection–injected in the soft fatty layer of tissue
  • Transparent body—for visual confirmation of the amount of dose administered

What can I expect during my visit?

  • The injection is given to you by a healthcare provider in the upper buttock, and it takes 20 seconds to complete
  • The injection site should alternate every 28 days between the right and left buttock
  • Remember to remind your doctor that your skin must be spread (and not pinched) when you receive the injection
  • If you’re already being treated to slow the growth of your GEP-NETs, your doctor does not need to give you an additional dose to treat carcinoid syndrome

For more information on what to expect during your visit, refer to the Patient Information and talk to your healthcare provider.

How does it work in the body?

Somatuline Depot contains lanreotide, a synthetic, or man-made, version of a hormone called somatostatin, which is found naturally in the human body.

It is believed that each injection forms a reservoir of the medicine between the skin surface and the muscle beneath—in an area called the deep subcutaneous tissue.

Somatuline Depot is slowly released into the bloodstream, which is why you’re able to receive it at 1-month intervals.


Helpful tips


Try to wear loose clothing or loose-fitting pants at your visit

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It is important to ask your healthcare provider if the medication is at room temperature (if the medicine is too cold, it may be painful)

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If you need help keeping track of your symptoms and injection sites, please view our downloadable resources here


  • Do not take SOMATULINE DEPOT if you are allergic to lanreotide.
  • SOMATULINE DEPOT may cause serious side effects, including:
    • Gallstones 
    • Changes to your blood sugar (high or low blood sugar),
    • Slow heart rate, and 
    • High blood pressure.
  • Tell your healthcare provider (HCP) if you have any of the following symptoms:
    • Symptoms of gallstones may include sudden pain in your upper right stomach area (abdomen), sudden pain in your right shoulder or between your shoulder blades, yellowing of your skin and whites of your eyes, fever with chills, and nausea.
    • Symptoms of high blood sugar may include increased thirst, increased appetite, nausea, weakness or tiredness, urinating more than normal, and fruity smelling breath.
    • Symptoms of low blood sugar may include dizziness or lightheadedness, sweating, confusion, headache, blurred vision, slurred speech, shakiness, fast heartbeat, irritability or mood changes, and hunger.
    • Symptoms of slow heart rate may include dizziness or lightheadedness, fainting or near-fainting, chest pain, shortness of breath, confusion or memory problems, and weakness or extreme tiredness.
  • The most common side effects of SOMATULINE DEPOT in people with:  
    • GEP-NETs: stomach area (abdominal) pain; muscle and joint aches; vomiting; headache; pain, itching or a lump at the injection site
    • Carcinoid syndrome: headache, dizziness, muscle spasm; side effects were generally similar to those commonly seen with GEP‑NETs

SOMATULINE DEPOT may cause dizziness. If this happens, do not drive a car or operate machinery. 
Tell your HCP right away if you have signs of an allergic reaction after receiving SOMATULINE DEPOT, including swelling of your face, lips or tongue; breathing problems; fainting, dizziness or feeling lightheaded (low blood pressure); itching; skin flushing or redness; rash; or hives.

  • Before taking SOMATULINE DEPOT, tell your HCP about all your medical conditions including if you: have diabetes; have gallbladder, heart, thyroid, kidney or liver problems; are pregnant or plan to become pregnant; or are breastfeeding or plan to breastfeed. It is not known if SOMATULINE DEPOT will harm your unborn baby or pass into breast milk. You should not breastfeed if you receive SOMATULINE DEPOT and for 6 months after your last dose. SOMATULINE DEPOT may affect your ability to become pregnant.
  • Tell your HCP about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. SOMATULINE DEPOT and other medicines may affect each other, causing side effects. SOMATULINE DEPOT may affect the way other medicines work, and other medicines may affect how SOMATULINE DEPOT works. Your dose of SOMATULINE DEPOT or your other medications may need to be changed. If you have diabetes, your HCP may change your dose of diabetes medication when you first start receiving SOMATULINE DEPOT or if your dose of SOMATULINE DEPOT is changed.
  • Especially tell your HCP if you take: 
    • Insulin or other diabetes medicines,
    • A cyclosporine (Gengraf, Neoral, or Sandimmune), or
    • Medicines that lower your heart rate, such as beta blockers.
    • Know the medicines you take. Keep a list of them to show your HCP when you get a new medicine.

Tell your HCP if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of SOMATULINE DEPOT. For more information, ask your HCP.

To report SUSPECTED ADVERSE REACTIONS, contact Ipsen Biopharmaceuticals, Inc. at 1-855-463-5127 or FDA at 1-800-FDA-1088 or

What is SOMATULINE® DEPOT (lanreotide) Injection? 

SOMATULINE DEPOT is a prescription medicine used in adults for:

  • the treatment of a type of cancer known as neuroendocrine tumors, from the gastrointestinal tract or the pancreas (GEP-NETs) that has spread or cannot be removed by surgery; and
  • the treatment of carcinoid syndrome to reduce the need for the use of short-acting somatostatin medicine.

It is not known if SOMATULINE DEPOT is safe and effective in children.

Somatuline Depot is a registered trademark of Ipsen Pharma S.A.S.
IPSEN CARES is a registered trademark of Ipsen S.A.
All other trademarks and registered trademarks are the property of their respective owners.

© 2023 Ipsen Biopharmaceuticals Inc. All rights reserved. December 2023 SMD-US-004048 v5.0