Explore 3 reasons with your doctor why Somatuline Depot may be an option for you

Somatuline® Depot (lanreotide) for GEP-NETs

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Slow the growth of GEP-NETs

In adults whose disease has spread or cannot be removed by surgery

Somatuline Depot reduced the risk of disease progression or death by 53% versus placebo.

At 22 months, more than half of the patients taking Somatuline Depot did not yet have their cancer progress. For those taking placebo, it took 16.6 months until half the patients had their cancer progress.

How Somatuline Depot was studied

  • Somatuline Depot was studied for nearly 2 years in 204 adult patients with various types of GEP-NETs that had spread or could not be removed by surgery. In some patients, the cancer started in their pancreas. In others, it started in a different place, such as their intestinal tract, which includes the colon
  • Patients in the study were divided into 2 groups, which received either Somatuline Depot 120 mg or placebo by deep subcutaneous injection every 4 weeks
  • The primary goal of this study was to determine if Somatuline Depot improved progression-free survival, which is the amount of time it took for the disease to progress

Learn about the possible side effects of Somatuline Depot

Somatuline®  Depot(lanreotide) for Carcinoid Syndrome

Carcinoid syndrome

Somatuline Depot is FDA-approved to treat adults with carcinoid syndrome to reduce the need for the use of short-acting somatostatin medicine. It is not known if Somatuline Depot is safe and effective in children.


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 Somatuline® Depot (lanreotide) patient

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Once-monthly, sustained-release injection

Somatuline Depot is approved as a deep subcutaneous injection given every 4 weeks by a healthcare provider. Your healthcare provider may change your dose of Somatuline Depot or the length of time between your injections.

Somatuline® Depot single-use syringe Safe'n'Sound® technology

Safe’n’Sound® syringe technology. Safe’n’Sound is a registered trademark of NEMERA LA VERPILLIERE SAS.

Not actual size.

Somatuline Depot is given by your healthcare provider as a low-volume, single-use syringe

  • Somatuline Depot is injected deep under the skin of the upper outer area of your buttock
  • Your injection site should change (alternate) between your right and left buttock from one injection of Somatuline Depot to the next
  • If you're already being treated with Somatuline Depot for GEP-NETs, your doctor will not give you an additional dose to treat carcinoid syndrome

How Somatuline Depot works

  • Somatuline Depot contains lanreotide, a synthetic, or man-made, version of a hormone called somatostatin, which is found naturally in the human body
  • It is believed that each injection forms a reservoir of the medicine between the skin surface and the muscle beneath—in an area called the deep subcutaneous tissue
  • Over time, tiny parts of the reservoir are slowly released into your bloodstream, to deliver the medicine to the rest of your body. This innovative formulation is what allows Somatuline Depot to be slowly released over the course of a month
Representation of deep subcutaneous Injection

The medicine reservoir is made up of tightly packed, microscopic nanotubes—which is what allows for the low injection volume of Somatuline Depot.


Somatuline Depot is slowly released into the bloodstream, which is why you’re able to receive it at 1-month intervals.

Facts about Somatuline Depot

Somatuline Depot (pronounced So-mat-u-leen Dee-poh) contains lanreotide, a synthetic, or man-made, version of a hormone called somatostatin, which is found naturally in the human body. Natural somatostatin helps to control the release of many different types of hormones.

tooltip close Hormones, one of the many substances produced by glands all over the body, circulate in the bloodstream and control the actions of certain cells or organs.

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